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Year : 2023  |  Volume : 8  |  Issue : 3  |  Page : 262-270

Pharmaceutical evaluation of modified Kantakari Avaleha for pediatric use

1 Department of Kaumarbhritya, ITRA, Rajkot, India
2 Department of RSBK, Indian Institute of Ayurved Research and Hospital, Rajkot, India
3 Department of Pharmaceutical Laboratory, ITRA, Jamnagar, Gujarat, India
4 Department of Microbiology Laboratory, ITRA, Jamnagar, Gujarat, India
5 Department of Pharmacognosy Laboratory, ITRA, Jamnagar, Gujarat, India

Correspondence Address:
Dr. Sagar Mahendrabhai Bhinde
Department of Kaumarbhritya, 533, 5th Floor, ITRA Institute Building, Jamnagar 361 008, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdras.jdras_144_22

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BACKGROUND: Kantakari Avaleha (KA) is a semisolid herbal drugs preparation recommended for various diseases like Hikka (hiccup), Kasa (cough), Shvasha (dyspnoea/asthma), and Shoola (colicky pain) in Sharangdhara Samhita. In this study, KA was slightly modified (after an experiment of classical and intermediate batches) by adding sugar and honey 1.5 and 2 times, respectively, in comparison to the classical method, to overcome its palatability issues in the pediatric age group. It is important to standardize the modified drug to make the drug formulation reproducible. Hence, the present study was aimed to evaluate pharmacognostical and pharmaceutical parameters of the modified Kantakari Avaleha (MKA) prepared for pediatric use. METHODS: Preauthenticated raw drugs were procured from pharmacy, ITRA, Jamnagar, Gujarat, India, and two pilot batches and final modified KA were prepared at RSBK Department, ITRA, Jamnagar. Samples from all three Avaleha were evaluated for organoleptic parameters and microbial study; samples from MKA were evaluated for pharmacognocy, physicochemical parameters, and high-performance thin-layer chromatography. RESULTS: Taste of MKA was improved compared to classical and intermediate formulations. Stability in terms of microbial overgrowth remains the same as the classical one. All the other evaluated parameters were comparable with Ayurveda Pharmacopeia of India standards except total, reducing and nonreducing sugar content. CONCLUSION: MKA was found to be palatable for pediatric use. The pharmacognostical and physico-chemical evaluation of final formulation revealed that this modified formulation meets almost all the pharmacopeial parameters (except sugar content) and hence data of the current study could be used as pharmaceutical standards for this specific MKA. Clinical study will be needed to determine whether the change in the proportion of sugar and honey has a favorable or negative impact on the clinical outcome.

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