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Year : 2023  |  Volume : 8  |  Issue : 3  |  Page : 223-229

Pharmaceutical development of Lekhaniya Mahakashaya into dispersible tablet–A polyherbal formulation

1 Department of Rasashastra and Bhaishajya Kalpana, KAHER’s Shri BMK Ayurveda Mahavidyalaya, Belagavi, Karnataka, India
2 Department of Quality Assurance, KAHER’s College of Pharmacy, Belagavi, Karnataka, India

Correspondence Address:
Dr. Rajendraswami S Hiremath
Department of Rasashastra and Bhaishajya Kalpana, KAHER’s Shri B.M.K. Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka 590003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdras.jdras_62_22

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BACKGROUND: Lekhaniya Mahakashaya (LM) is indicated in Ayurveda for obesity. Its classical dosage form is Kashaya (decoction), which involves time-consuming preparation and has a low shelf-life. The aim of the study was, therefore, to modify the dosage form of LM into a dispersible tablet (DT), a unit solid dosage form close to decoction, due to its conversion into aqueous solution during administration. METHODS: Raw materials were authenticated as per API standards. To develop and optimize the DT, totally six trials for each of the 30 tablets were carried out by direct compression method using two super disintegrants, viz., Sodium Starch Glycolate (SSG) and Croscarmellose Sodium, with the effervescent agents, tartaric acid, and sodium bicarbohydrate. The developed formulation was analyzed for its pre- and post-compression parameters besides Fourier transform infrared (FTIR). RESULTS: The formulation made using Anhydrous Lactose (AL) as a binding agent and SSG as a super disintegrant passed all the quality parameters of a DT. The average weight was 500 mg. The angle of repose was 0.600, Carr’s index was 19.40, and Hausner’s ratio was 1.24. Disintegration time was 2.5 min, friability was less than 1%, hardness was 2.5, and weight variation was less than 5%. FTIR revealed the presence of functional groups such as phenolics, alcohol, alkene, and nitride. CONCLUSION: LM can be modified into a DT using AL as a binding agent and SSG as a super disintegrant. Further studies are warranted to fix the clinical dose and assess efficacy.

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