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ORIGINAL ARTICLE
Year : 2023  |  Volume : 8  |  Issue : 1  |  Page : 65-73

Neuroprotective role of Sida acuta Burm. f. in scopolamine-induced memory impairment rat model: An electrophysiological and behavioral study


1 Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
2 Department of Pharmaceutical Engineering and Technology, Indian Institutes of Technology, Banaras Hindu University, Varanasi, India
3 Department of Dravyaguna, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
4 Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Manmath Kumar Nandi
Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdras.jdras_74_22

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BACKGROUND: In the present study, neuropharmacological effect of Sida acuta root extract was investigated by in vitro and in vivo experimental models. METHODS: In in vitro electrophysiological study, hippocampal slices of the albino rats’ brain were treated with three different concentrations of the extract (0.25, 0.5, and 1 mg/mL). Field excitatory postsynaptic potential slope (mV/ms) was assessed. In in vivo study, plant extract was given at three different doses (50, 100, and 200 mg/kg b.w., p.o.). Piracetam (200 mg/kg i.p.) was used as a standard drug and scopolamine (1 mg/kg, i.p.) was used to induce dementia in rats. The effect of extract was assessed using elevated plus maze and Barnes maze model. RESULTS: The in vitro result showed reduction in the amplitude of field excitatory postsynaptic potential slope after wash in the extract at 0.25 mg/mL, 0.5 mg/mL, and 1 mg/mL due to the partial blockage of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. In vivo study reveals that scopolamine-treated rats exhibited delayed latency time in elevated plus maze and Barnes maze, as well as numbers of error were also increased in Barnes maze as compared to the control. Animals treated with piracetam and root extract (200 mg/kg) reduced the effect of scopolamine-induced dementia to a great extent. CONCLUSION: This finding reveals that Sida acuta root extract has cognitive enhancing activity.


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