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1.  Review Article
Ayurveda and Plant-based Interventions for Cancer Management: A Systematic Review
Manohar S Gundeti, Narayanam Srikanth, Amrish Dedge, Shruti Khanduri, Parth Dave, Ashish Kumar Tripathi, Thrigulla Sakethram, R Govind Reddy
[Year:2017] [Month:April-June] [Volume:2 ] [Number:2] [Pages:108] [Pages No:64-80] [No of Hits : 1654]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0009 | FREE

ABSTRACT

Introduction: A resurgence of interest in Ayurveda, other traditional systems of medicine, and complementary and alternative medicine (CAM) has resulted from the preference of many consumers for products of natural origin. The potential benefits of plant-based medicines could lie in their high acceptance by patients, and efficacy and safety. The most prevalent users of traditional medicine are individuals who have refractory conditions and nonlife-threatening conditions that may be chronic viz. neurological disorders, arthritis, etc. The second-largest group of users is those struggling with chronic, potentially life-threatening diseases, such as cancer and human immunodeficiency virus/acquired immunodeficiency syndrome, etc. Both groups turn to Ayurveda and traditional system of medicine for a variety of reasons, such as management as the main treatment option and improved immune functioning, overall functioning, and quality-of-life (QoL) by coping with side effects from conventional therapies, and to relieve symptoms related to their illness. The upsurge in use of traditional system among cancer patients warrants evidence of safety and effectiveness for these interventions as concomitant to conventional cancer therapy.

Objective: This manuscript aims at a systematic review of published data on the effectiveness of Ayurveda/ herbal interventions as stand-alone or concomitant in the management of cancer.

Materials and methods: Literature search for clinical studies with specific terms was carried using search engines viz. Google scholar, PubMed, Ayush Research Portal, etc. and print journals, reports from May 2017 to June 2017.

Results: Various randomized controlled trials (RCTs) have shown that ginger, honey, turmeric, and ashwagandha are effective as add-on in chemotherapy-induced nausea and vomiting (CINV), radiation mucositis, and fatigue. Moreover, single case reports and case-control studies also reported with positive outcomes for Ayurveda as stand-alone and add-ons to conventional treatment.

Conclusion: Evidence for effectiveness of Ayurveda as add-on concomitant to conventional cancer treatment is substantial in comparison with Ayurveda as stand-alone, and this may help to develop integrative Ayurveda oncology treatment protocols.

Keywords: Ayurveda, Cancer, Integrative, Oncology, Plant.

How to cite this article: Gundeti MS, Srikanth N, Dedge A, Khanduri S, Dave P, Tripathi AK, Sakethram T, Reddy RG. Ayurveda and Plant-based Interventions for Cancer Management: A Systematic Review. J Drug Res Ayurvedic Sci 2017;2(2):64-80.

Source of support: Nil

Conflict of interest: None

 
2.  Research Article
Concept of Stability Study of Churna Kalpana
Neetu, Harish K Singhal, Khem Chand Sharma
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:34-39] [No of Hits : 1429]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0006 | FREE

ABSTRACT

A common myth exists among people that Ayurvedic medicines do not have an expiry date, but it is not true. Concept behind expiry means that after a certain period, the substance that is used as medicine undergoes changes, which make it ineffective. That period is known as expiry date or shelf life in modern system of medicine. This concept was described in 14th century by Acharya Sharangdhar as Saviryata Awadhi in his textbook Sharangdhar Samhita. Recent development in the field of Ayurvedic pharma industries has reestablished old principles through evidences. Among the description of all five primary dosage forms, Churna (powder) has been considered in this study. There are numerous factors that affect its shelf life, which have been discussed in this study. Based on that, we conclude that by improving storage conditions, adding additives and preservatives, degradation of Churna can be checked.

Keywords: Churna, Shelf life, Stability.

How to cite this article: Neetu, Singhal HK, Sharma KC. Concept of Stability Study of Churna Kalpana. J Drug Res Ayurvedic Sci 2017;2(1):34-39.

Source of support: Nil

Conflict of interest: None

 
3.  Research Article
Utilization of Some Important Herbs used as “Śāka” (Vegetable) in Ayurveda by Tribal People of Raigarh District, Chhattisgarh State, India
Sanjeev Kumar Lale, Sugriv Kumar Gaur
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:40-48] [No of Hits : 851]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0007 | FREE

ABSTRACT

There are a large number of classical Ayurvedic plants that are used as vegetables by tribal communities of Raigarh district. These plants profusely grow on wastelands that are free of insecticides/pesticides and give new relish vegetables. These vegetables are not popular among common people or they feel inferior to accept these vegetables in their diet. The consumption of such important plant resources should be popularized as they could be beneficial resource for prevention, management, and treatment of chronic diseases. The present study deals with the medicobotanical survey work of Dharmajaygarh and Raigarh forest divisions of Raigarh district, Chhattisgarh, India. These vegetables are arranged in their useful part, e.g., leaf, fruit, tuber, etc., their Ayurvedic name, local name, botanical name, family, and part used followed by their Ayurvedic and local uses. The study revealed the utilization of 31 classical Ayurvedic vegetables (saka) by tribal people of Raigarh district. Vegetables like Enhydra fluctuans Lour., Corchorus capsularis L., Leucas cephalotes (Roth) Spreng., Boerhavia diffusa L., Senna tora (L.) Roxb., Celosia argentea L., Lathyrus sativus L., Centella asiatica (L.) Urb., Tamilnadia uliginosa (Retz.) Tirveng. & Sastre, Dioscorea alata L., etc., are unique in this area. The study suggests that the inclusion of these herbs in the regular diet of common people helps in prevention and management of various ailments.

Keywords: Ayurveda, Herbs, Raigarh district, Śāka, Vegetable.

How to cite this article: Lale SK, Gaur SK. Utilization of Some Important Herbs used as “Śāka” (Vegetable) in Ayurveda by Tribal People of Raigarh District, Chhattisgarh State, India. J Drug Res Ayurvedic Sci 2017;2(1):40-49.

Source of support: Nil

Conflict of interest: None

 
4.  Research Article
In vitro Studies on Antidiabetic Potential of New Dosage Forms of AYUSH 82
M Setia, K Meena, A Madaan, Narayanam Srikanth, Kartar S Dhiman, JLN Sastry
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:1-9] [No of Hits : 805]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0001 | FREE

ABSTRACT

AYUSH 82 powder is an Ayurvedic antidiabetic formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, Government of India. It comprises ingredients traditionally used for their beneficial effect in diabetes (Prameha/Madhumeha). The hypoglycemic effects of AYUSH 82 powder have been reported in diabetic subjects. In the current study, the antidiabetic potential of AYUSH 82 powder along with its two new dosage forms - AYUSH 82 mixture extract and AYUSH 82 compound extractwas investigated in vitro for elucidating mechanism of their action by possible α-amylase inhibitory property, insulindependent glucose uptake in skeletal muscle cell line (C2C12 myotubes), and effect on peroxisome proliferator-activated receptor gamma (PPAR-γ) activity.

All the three dosage forms of AYUSH 82 - powder, mixture extract, and compound extract - exhibited inhibition of á-amylase activity. AYUSH 82 mixture extract, however, demonstrated highest extent of inhibition in both methanolic (87.4%) and aqueous (48.2%) format. All the three dosage forms of AYUSH 82 also demonstrated an increase in insulin-dependent glucose uptake in C2C12 myotubes as compared with control. However, none of the test items (TIs) exhibited activation of PPAR-γ expression in tested ranges, indicating that antidiabetic potential of TIs may not be mediated via PPAR-γ activation. Results indicated that the new dosage forms of AYUSH 82 (mixture extract and compound extract) may be useful for making new dosage forms of AYUSH 82 as tablets/capsule, etc.

Keywords: α -Amylase, A ntidiabetic a ctivity, A YUSH 82 powder, Compound extract, Glucose uptake assay, Mixture extract, Peroxisome proliferator-activated receptor gamma

How to cite this article: Setia M, Meena K, Madaan A, Srikanth N, Dhiman KS, Sastry JLN. In vitro Studies on Antidiabetic Potential of New Dosage Forms of AYUSH 82. J Drug Res Ayurvedic Sci 2017;2(1):1-9.

Source of support: Nil

Conflict of interest: None

 
5.  Review Article
Indigenous Medicinal Plants of Northeast India in Human Health: Literary Note
Rama Shankar, Ashish Kumar Tripathi, Gyati Anku, Shazia Neyaz, Mohan S Rawat
[Year:2017] [Month:April-June] [Volume:2 ] [Number:2] [Pages:108] [Pages No:104-117] [No of Hits : 700]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0012 | FREE

ABSTRACT

Objective: This study was conducted to prepare records of medicinal plants used in various traditional practices in Northeast India for the management of different diseases.

Introduction: Northeastern region comprises the states of Arunachal Pradesh, Assam, Manipur, Meghalaya, Mizoram, Nagaland, Tripura, and Sikkim. Topography of the region which is the prime source of diversity of flora and fauna covering the part of natural medicine is from tropical, subtropical, temperate, and alpine regions of vegetation distribution. This topography reflects the occurrence of diverse types of medicinal plants suitable for different climatic conditions. The study deals with the medicinal plants used in the management of various prevalent diseases in Northeast India by the use of locally available herbs.

Outcome: Medicinal plants distributed in the different climatic zones of Northeast are Aconitum heterophyllum, Acer palmatum, Adiantum capillus veneris, A. lunulatum, Aquilaria malaccensis, Bacopa monnieri, Berberis aristata, B. wallichiana, Bergenia ciliata, Curcuma caesia, C. zedoaria, Crateva nurvela, Cordyceps sinensis, Embelia ribes, Emblica officinalis, Gentiana kurroo, Gmelina arborea, Gynocardia odorata, Hydnocarpus kurzii, Nardostachys jatamansi, Panax pseudoginseng, Paris polyphylla, Picrorhiza kurrooa, Rauvolfia serpentina, Rubia manjith, Saraca asoca, Solanum nigrum, Taxus wallichiana, Terminalia arjuna, T. bellerica, T. chebula, T. citrina, Valeriana jatamansi, Zanthoxylum armatum, Z. rhetsa, Zingiber zerumbet, Z. officinale, etc.

Conclusion: The commercial cultivation, systemic collection for trade is the mode through which local inhabitants may earn money for moving toward prosperity.

Keywords: Cultivation, Medicinal plants, Rubia manjith, Zanthoxylum armatum.

How to cite this article: Shankar R, Tripathi AK, Anku G, Neyaz S, Rawat MS. Indigenous Medicinal Plants of Northeast India in Human Health: Literary Note. J Drug Res Ayurvedic Sci 2017;2(2):104-117.

Source of support: Nil

Conflict of interest: None

 
6.  Review Article
Medico-ethno Botanical Survey: An Overview of CCRAS Contributions
Chinmay Rath, Bonthu Susmitha, Ashish K Tripathi, Mukesh B Chincholikar, Anupam K Mangal, Narayanam Srikanth
[Year:2017] [Month:July-September] [Volume:2 ] [Number:3] [Pages:88] [Pages No:188-240] [No of Hits : 699]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0019 | FREE

ABSTRACT

Aim: Medico-Ethno Botanical Survey (MEBS) was initiated by the Central Council for Research in Ayurvedic Sciences (CCRAS) in 1969 with the main aim of survey and documentation of medicinal plants of India used in Ayurveda system of medicine. Through its five peripheral institutes, namely Regional Ayurveda Research Institute for Metabolic Disorders (RARIMD)— Bengaluru, Regional Ayurveda Research Institute for Gastro- Intestinal Disorders (RARIGID)—Guwahati, Regional Ayurveda Research Institute (RARI)—Itanagar, RARI—Jhansi, and RARI—Ranikhet, the Council has surveyed every part of phytogeographic regions across the country, including the Andaman & Nicobar Islands and Lakshadweep. During these survey tours, various medicinal plants were collected and preserved as Herbarium and Museum specimens. The survey team collects and supplies authentic raw drug samples for studies under various projects inside and outside the Council, including the projects under Central Scheme of Ayurvedic Pharmacopoeia Committee (APC). Herbarium and Museum centers located in various institutes of CCRAS are being used as reference centers for UG/PG/M.Phil./Ph.D. students and researchers for correct identification/authentication of their plant specimens or raw drug materials. Further, the folk-claims collected during the exploration work provide lead for validation and effective development of drugs based on traditional knowledge and not from any codified system of medicine. Ayurvedic ancient texts also explain the importance of medicinal plant survey.

Materials and methods: The gross physical achievements including the beneficiaries of MEBS, details of forest divisions, medicinal plant species collected, and preparation of Herbarium specimens during the reporting period 1969 to 2016 were compiled, summarized, and presented based on the information available in the published monographs, technical reports, and annual reports of CCRAS.

Conclusion: India is rich in its diverse natural resources and treated as one of the biggest natural biodiversity countries of the world. The cultural diversity in the country is represented by many cultural groups, including the tribes and others. The contributions of CCRAS are significant in extending Medico- Ethno Botanical Program across the country and also preserving the valuable ethnomedical knowledge prevailing among tribal communities through systematic survey, identification, preservation, documentation, and validation of medicinal plants.

Keywords: Central Council for Research in Ayurvedic Sciences, Medicinal plant species, Medico-Ethno Botanical Survey.

How to cite this article: Rath C, Susmitha B, Tripathi AK, Chincholikar MB, Mangal AK, Srikanth N. Medico-Ethno Botanical Survey: An Overview of CCRAS Contributions. J Drug Res Ayurvedic Sci 2017;2(3):188-240.

Source of support: Nil

Conflict of interest: None

 
7.  Review Article
Pharmacological Profile of Tithonia diversifolia (Hemsl) A. Gray: A Comprehensive Review
Lalrinpuia Kawlni, Manajit Bora, Sachchida N Upadhyay, Jayram Hazra
[Year:2017] [Month:July-September] [Volume:2 ] [Number:3] [Pages:88] [Pages No:183-187] [No of Hits : 615]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0018 | FREE

ABSTRACT

Aim: This review aims to provide an up-to-date overview of pharmacological studies of Tithonia diversifolia (Hemsl.) A.Gray. Moreover, the focus of this review is the possible exploitation of this species to treat different diseases and to suggest future investigations.

Background: Tithonia diversifolia (Hemsl.) A.Gray is an important medicinal plant whose leaf is the major organ used alone or in combination with other plants for the treatment of a wide variety of ailments. This plant has been a subject of research interest because of its various indigenous medicinal uses in many countries.

Results: Different pharmacological studies on T. deversifolia show that it possesses antibacterial, antioxidant, anti-inflammatory, antinociception, analgesic, antidiarrheal, antimalarial, antihyperglycemic, and cancer chemopreventive activities due to the presence of different active constituents.

Conclusion: Tithonia diversifolia (Hemsl.) A.Gray extracts and their active constituents should be subjected to detailed mechanistic studies to fully understand the mode of action of the active constituents.

Clinical significance: Till date, there is no scientific literature/ data regarding clinical trials of this plant except preclinical studies on different laboratory animals.

Keywords: Pharmacological studies, Therapeutic uses, Tithonia diversifolia, Traditional medicine.

How to cite this article: Kawlni L, Bora M, Upadhyay SN, Hazra J. Pharmacological Profile of Tithonia diversifolia (Hemsl.) A.Gray: A Comprehensive Review. J Drug Res Ayurvedic Sci 2017;2(3):183-187.

Source of support: Nil

Conflict of interest: None

 
8.  Review Article
Antiasthmatic Potential of Shirisha (Albizia lebbeck (L.) Benth)
Raman Kaushik, Varanasi Subhose, Deepak Londhe, Om Prakash
[Year:2017] [Month:October-December] [Volume:2 ] [Number:4] [Pages:66] [Pages No:295-300] [No of Hits : 600]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0026 | FREE

ABSTRACT

Background: Medicinal plants or their preparations play a major role in the prevention, treatment of various diseases as well as improve quality of life with maintenance of health. Bronchial asthma is a common respiratory disease that affects about 18% of world’s population. In Ayurveda perspective, bronchial asthma along with other conditions related to difficulty in breathing is described under shwasa roga. Numerous herbs have been described in Ayurveda treatises that are useful in shwasa roga, and shirisha (A. lebbeck) is one among them.

Aim: To critically analyze the antiasthmatic activity of Medicinal plants shirisha (Albizia lebbeck) and its importance in the management of shwasa roga.

Results: This review study mainly focuses on the shwasahara karma, i.e., antiasthmatic action of a popular Medicinal plants, specifically Shirisha. Various research papers and studies have been reviewed and referred in the present study to establish the antiinflammatory, hepatoprotective, eosinophil lowering, mast cell stabilizing, immunomodulatory, antihistaminic, and antiasthmatic action of shirisha. Other than its use as a single drug, there are different ayurvedic formulations indicated in shwasa roga that have shirisha as one of their main contents.

Conclusion: Despite various uses of shirisha in different disease conditions, shirisha has very effective antiasthmatic action. Several research studies (both in vitro and in vivo) have been done that establishes antiasthmatic, antiinflammatory, antihistaminic, etc. activity of shirisha. It is concluded that shirish (A. lebbeck) is a very competent medicinal plant that can be used as a single herb or in formulation in the management of bronchial asthma.

Clinical significance: Shirish is an excellent Medicinal plant that possesses promising bronchodilation, antiinflammatory, and antiasthmatic activity. Shirisha can be used as a single herb or in compound formulation in asthmatic patients. Including such kind of medicinal plants can minimize the dependency on inhalers, reduces the frequency as well as duration of acute or chronic cases of asthma.

Keywords: Albizia lebbeck, Antiasthmatic, Bronchial asthma, Shirisha, Shwasa roga.

How to cite this article: Kaushik R, Subhose V, Londhe D, Prakash O. Antiasthmatic Potential of Shirisha (Albizia lebbeck (L.) Benth). J Drug Res Ayurvedic Sci 2017;2(4):295-300.

Source of support: Nil

Conflict of interest: None

 
9.  Research Article
Microscopical and Preliminary Physicochemical Studies of Two Important Endangered Ayurvedic Medicinal Plants Kutki and Trayamana to establish their Identity
Anupam K Mangal, Chinmay Rath, Devesh Tewari, Sreya Dutta, Narayanam Srikanth, Kartar S Dhiman
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:18-22] [No of Hits : 592]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0003 | FREE

ABSTRACT

Kutki is an important Ayurvedic drug native to the Himalayan region, and its official source is Picrorhiza kurroa Royle ex Benth., belonging to the family Scrophulariaceae. The plant is a small, hairy perennial herb with creeping and woody rhizome and used in various Ayurvedic medicines. It is useful as a laxative, liverstimulant, galactogouge, and appetite-stimulant and is beneficial in bronchial asthma. Due to its high demand, the plant is often adulterated/substituted with the roots of Trayamana (Gentiana kurroo Royle), as one of the source of the Kutki. The present study has focused to establish the identity of Picrorhiza kurroa Royle ex Benth through microscopical investigations and comparison of the genuine drug with its substitute Gentiana kurroo Royle. Powder of the rhizomes of Picrorhiza kurroa Royle ex Benth. and roots of Gentiana kurroo Royle were subjected to microscopic characterization and physicochemical analysis, which would not only serve in the identification of both the drugs, but also contribute toward establishing pharmacopoeial standards.

Keywords: Ayurvedic, Endangered, High altitude, Kutaki, Microscopy, Rhizomes, Trayamana.

How to cite this article: Mangal AK, Rath C, Tewari D, Dutta S, Srikanth N, Dhiman KS. Microscopical and Preliminary Physicochemical Studies of Two Important Endangered Ayurvedic Medicinal Plants Kutki and Trayamana to establish their Identity. J Drug Res Ayurvedic Sci 2017;2(1):18-22.

Source of support: Nil

Conflict of interest: None

 
10.  Research Article
Pharmacognostical and Histochemical Studies on Apakva Kadali (Unripe Banana Fruit): Musa × paradisiaca L.
Shantha T Ramasheshan, Prathapa R Maramreddy, Patchaimal Pitchaiah, Kishore K Ramakrishana, Vandana Bharti, Venkateshwarlu Gaddam, Devesh Tewari, Anupam K Mangal, Narayanam Srikanth, Kartar S Dhiman
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:10-17] [No of Hits : 589]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0002 | FREE

ABSTRACT

The unripe fruit of Musa × paradisiaca L., classically known as apakva kadali, belonging to the family Musaceae, is used as pathya in atisara (diarrhea), in grahani (irritable bowel syndrome), and agnimandya (loss of appetite). The unripe fruits are considered to be helpful in the management of diabetes mellitus. Being an important medicinal plant, the present investigation is an attempt to explore the pharmacognostical analysis and thin-layer chromatography fingerprint studies on the widely used Musa. × paradisiaca L. The studies revealed that unripe banana fruit showed the presence of small outer protrusion of papillae on the epidermis, abundant tannin-containing cells in the epicarp and mesocarp. Elongated air-spaced cells are surrounded by the parenchyma cells in the epicarp, abundant starch grains in the mesocarp portion, and acicular crystals of calcium oxalate in raphide bundles. To detect the location of various constituents of the drug, sections of unripe fruits were treated with various reagents, and studies showed the presence of phenols, protein, calcium oxalate, magnesium, starch, cellulose, calcium pectate, lignin, sulfated mucopolysaccharides, tannin, and silica contents. Phytochemical studies showed the presence of alkaloids, carbohydrates, phenols, proteins, starch, tannins, steroids, and saponins.

Keywords: Antidiabetic, Histochemical, Microscopy, Musa paradisiaca, Phytochemical, Unripe fruit.

How to cite this article: Ramasheshan ST, Maramreddy PR, Pitchaiah P, Ramakrishana KK, Bharti V, Gaddam V, Tewari D, Mangal AK, Srikanth N, Dhiman KS. Pharmacognostical and Histochemical Studies on Apakva Kadali (Unripe Banana Fruit): Musa × paradisiaca L. J Drug Res Ayurvedic Sci 2017;2(1):10-17.

Source of support: Nil

Conflict of interest: None

 
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